s Republic

Jessica Antolini September 29, 1999 Phil. 1050 – Plato Paper Prof. Michael Shaw Virtue: conformity to a standard of right (Merriam- Webster, 812) . Virtues contribute to people’s actions in today’s society. Society as a whole has a common set of virtues that many people agree on. In today’s society, these are known as laws. Virtues also mold the individual outlook on life, and give them the moral’s to do what is right. In The Republic, Plato divides the city into three classes: gold, silver, as well as bronze and iron souls. Each class is designated to posses a specific virtue. He believes that wisdom, courage, moderation, and justice combine together to form The Republic. However, Plato’s four virtues individually do not necessarily produce a utopian society. A combination of the four in each citizen is imperative in producing the ideal society. In Plato’s search for the perfect â€Å"republic†, he decides that the basis of the city will be on four virtues. The first of them is wisdom. Plato defines wisdom, in Greek terms â€Å"Sophia†, as knowledge of the city as a whole. Of the three classes, the gold souls posses the virtue of wisdom. The gold souls are the only class whose knowledge goes beyond the mere facts to the level of true wisdom. â€Å"†¦This class, which properly has a share in that knowledge which alone among the various kinds of knowledge ought to be called wisdom, has, as it seems, the fewest members by nature† (429a). The second virtue that Plato defines is courage, which in Greek terms is â€Å"Andreia†. Courage is the preservation of the opinion produced by law, through education about what things are terrible, and what things are good. Courage can be found in the silver souls. Plato uses the example that when dyers want to dye wool, they start with the background. They need the right kind of white material, and they have to prepare it carefully; and if they go to this trouble, you can not bleach the color... 's Republic Free Essays on Plato\'s Republic Jessica Antolini September 29, 1999 Phil. 1050 – Plato Paper Prof. Michael Shaw Virtue: conformity to a standard of right (Merriam- Webster, 812) . Virtues contribute to people’s actions in today’s society. Society as a whole has a common set of virtues that many people agree on. In today’s society, these are known as laws. Virtues also mold the individual outlook on life, and give them the moral’s to do what is right. In The Republic, Plato divides the city into three classes: gold, silver, as well as bronze and iron souls. Each class is designated to posses a specific virtue. He believes that wisdom, courage, moderation, and justice combine together to form The Republic. However, Plato’s four virtues individually do not necessarily produce a utopian society. A combination of the four in each citizen is imperative in producing the ideal society. In Plato’s search for the perfect â€Å"republic†, he decides that the basis of the city will be on four virtues. The first of them is wisdom. Plato defines wisdom, in Greek terms â€Å"Sophia†, as knowledge of the city as a whole. Of the three classes, the gold souls posses the virtue of wisdom. The gold souls are the only class whose knowledge goes beyond the mere facts to the level of true wisdom. â€Å"†¦This class, which properly has a share in that knowledge which alone among the various kinds of knowledge ought to be called wisdom, has, as it seems, the fewest members by nature† (429a). The second virtue that Plato defines is courage, which in Greek terms is â€Å"Andreia†. Courage is the preservation of the opinion produced by law, through education about what things are terrible, and what things are good. Courage can be found in the silver souls. Plato uses the example that when dyers want to dye wool, they start with the background. They need the right kind of white material, and they have to prepare it carefully; and if they go to this trouble, you can not bleach the color...

Greek Gods

Greek Gods With the development of stable communities, agriculture and writing, ancient man for the first time in history found himself with the leisure to ponder the nature of the universe and his role in it. These "ponderings" found their way into religious life as recited stories, and eventually on written records. These cultures had neither the technology nor the historical perspective to posit a natural explanation. Therefore, the genesis of these ancient cosmologies was embedded in supernatural myths. Though supernatural, these myths projected strong anthropomorphic and anthropocentric ontologies. Two examples of this mind set are the works of Hesiod, Theogany and Works and Days, and the first three chapters of Genesis in The Bible. An exploration of these works will demonstrate some of the similar and opposing views the ancient man held about the world he in which he lived.By examining basic tenets observed in these cosmogonies, certain comparisons may be drawn as well as many contrasts. Crouching Aphrodite, 1st–2nd century AD, from Sa...She could hardly ever be persuaded to lend it to anyone. Since Aphrodite had the magic girdle and was so beautiful, all of the gods fell in love with her. All of the goddesses were jealous of Aphrodite because all of the gods loved her instead of the other goddesses. Because of this, Zeus arranged a marriage for her with Hephaestus, the lame smith-god.Aphrodite, already regretting the trouble she had caused, took Adonis, and put him in a chest. She gave the chest to Persephone, asking her to hide it in a dark place. Persephone couldn't stand not knowing what was inside the chest, so she opened the chest and found Adonis. Persephone found Adonis to be a very cute baby, so she took hi into her own palace to raise him. Aphrodite did not find out about...

Picking up the Lego pieces - Lego's turnaround or not Essay

Picking up the Lego pieces - Lego's turnaround or not - Essay Example The result was a disaster. Lego adopted the diversification strategy of expanding its market to include girls and older boys and selling new and unrelated products like clothes, watches, video games and theme parks to these new markets. Like other companies that went beyond their core competence – in Lego’s case, making toys for 5-9 year-old boys – Lego failed miserably and lost money because market share spiraled downwards as it sold lesser products to lesser customers and incurred higher costs. The CEO hired in 2004, Jorgen Vig Knudstorp, changed the corporate strategy to one of focus and product differentiation. While Lego continued to expand its market to include older age groups, differentiation is not the same as diversification, and in this sense the Economist article was not entirely correct when it claimed â€Å"bits of the diversification strategy remained.† Lego continued to offer the same focused brand of â€Å"play for all† experience – Lego comes from the Danish leg godt which means â€Å"play well† – to a larger market and aligned the rest of the company to be profitably right-sized for it. Lego’s next steps delivered positive results and showed it could â€Å"diversify† into computer based games for an older age group, staying focused and pragmatic while building on its traditional brick-based products (Watts). Its blockbuster Bionicle and Mindstorm product lines led to profitable product extensions like Star Wars and Harry Potter, capitalizing on film tie-ins, and extended market reach to more countries, especially to emerging China and Japan, acknowledged to be Lego’s top market in Asia for construction category toys (McGinn; Lego Website). Cheaper products made in Asia and sold by Tyco under the Super Block brand eroded Lego’s market share in the 1980s. While Lego enjoys first mover advantage and continues to be number one in the construction category toy market, competitors are fighting a marketing war

Personal Action Plan Statement Example | Topics and Well Written Essays - 1000 words

Action Plan - Personal Statement Example The first thing scholars need to know how to do is an effective library and/or internet search. Before a search can be started the student needs to choose keywords which will narrow down the search criteria. For example, if a student is considering doing a paper on the Civil War and reconstruction then those would be your keywords. However, if you are given a broad subject area then you will need to narrow down your search. For example, you need to write a 10 page research paper in American History to 1877. That includes a large number of topics. During the course of the class you are drawn to the Jacksonian Era, so you decide to write a paper about Andrew Jackson. Next you need to narrow down even more because Andrew Jackson is just too big of a topic for a 10 page paper. So you decide to do your paper on his term as the President. That narrows down your time frame to just eight years, manageable but still too big for your assignment. Next decide on what aspect of Andrew Jackson Pre sidency you are going to focus on. You find yourself interested in the Nullification Crisis that involved South Carolina. Now you have a reasonable size topic for a paper and your keywords would be: Andrew Jackson, Nullification, and South Carolina. These keywords allow a student to perform an effective library and/or internet search. ... All students should know and understand the definition of plagiarism. My definition of plagiarism is using somebody else's ideas or words in your own paper without giving them proper credit. An example of a plagiarized quote would be if you were to use a direct quote without offsetting it with quotation marks and not giving the original author credit. Another thing that you cannot do is just replace two or three words and call that a paraphrase. The safest thing to do is to summarize an author's main point in your own words. Another area of upholding academic honesty is to not cheat. This means that you personally will not cheat on papers or test. Yet, it also means that if you find another student cheating you have a responsibility to report him or her. My personal action plan for upholding academic honesty is to follow all posted school rules regarding academic honesty. Developing effective study skills consists of finding what works for you and using it to the best advantage possible. The most important elements of effective studying are lecture notes, reading notes, place, and time. The lecture notes are important because they tell you information that will be on the test. Lecture notes should be read immediately after the lecture and again in preparation for any test, at a minimum. Reading notes are notes taken while you are reading your textbooks. Some classes use regular text books and other classes will use novels, fiction and nonfiction, so you need to learn how to take notes on booth types of books. The place you study is important also. It should be a quite place where you will not be interrupted by friends and family. It should be comfortable but not so comfortable you fall asleep. It

The Arrest of Shiite Cleric Nimr Al-Nirm Essay Example | Topics and Well Written Essays - 750 words

The Arrest of Shiite Cleric Nimr Al-Nirm - Essay Example Analysis The cleric has always been critical of the government. In fact in 2009 he had called for the secession of the Eastern province. As things stand now Nimr’s role has been elevated from a mere regional cleric to the main focal point of the many disgruntled Shiite youths. The matter is complicated further by the fact that he resides in the town of Awamiya which is a hotbed of radicalism and is rife with weapons (Matthiesen, 2). There has been some information that the rise and prominence of the cleric had been instigated, boosted and funded by elements within the ruling family itself. It is believed that Nimr has been covertly encouraged and even financed by the hardliners in the royal family in order to scuttle the attempt by the king to reach out to the Shiite through the interfaith dialogue that he had initiated. Hardliners in the inner circle like Prince Naif bin Abdullazziz. The Interior Minister did not want to see this peace initiative succeed (Press TV, 1). The part that raised questions is the timing of the arrest. It is more than two years now since he started his so called campaign against the ruling family. Protests that had been taking place in the Eastern province had all but died down. Much of the mass actions in terms of demonstrations had fizzled out. In fact, there had been no significant protests in the region since November 2011.The protests had largely lost steam and the region was relatively calm. So it is difficult to comprehend the decision to arrest the cleric now.

Diagnosing And Monitoring Of Thrombocytopenia Biology Essay

Diagnosing And Monitoring Of Thrombocytopenia Biology Essay Thrombocytopenia is a haematological condition marked by a decrease in platelet number in peripheral blood (5). To identify the source, it is important to understand the mechanism of platelet formation and its pathophysiology. 1.1.1 Role of platelets Platelets were first described in the 19th century as dust of blood(44, 45). Over the last 100 years, there have been many advances in understanding the role of platelets. These cells have a diameter of 2-3mm and have been identified as playing a crucial role in repairing of damaged blood vessels, in response to injury; achieved via a clotting mechanism and the involvement of various clotting factors (1). It is a continuous cascade, where one factor activates the next with the end product being a fibrin clot. Formation of the clot prevents blood loss, maintaining cell concentration within vessels. Under normal conditions, 11011 platelets are released from the bone marrow into circulation, which helps provide the balance between formation and sequestration (43). Larger platelets are considered to be more reactive and efficient at performing their role than mature platelets (11). During vascular damage, there is increased activity from cytokines, transcription and growth factors to res tore the balance, as more than 20-fold rise in cells are released into blood (45). 1.1.2 Thrombopoiesis Thrombopoiesis is the process of platelet formation, occurring in the bone marrow. The mature cells have a life span of 10 days and make up 5litres of the total blood volume; one third of which is found in the spleen due to platelet senescence (43). Thrombopoiesis consists of a negative feedback mechanism, regulated by the glycoprotein thrombopoietin (TPO) (43). TPO was named after erythropoietin in 1950, after being shown to have inducing capabilities in a study performed on rats with bleeding disorders (43). In the last decade, a greater understanding of the growth factor has been achieved (41). Its association with the cellular oncogene; cellular myeloproliferative leukaemia (c-Mpl) found on the surface of megarkaryocytes and platelets has been identified (40). TPO has a high affinity for c-Mpl (43). Research carried out in mice in 19__ showed 15% of patients with thrombocytopenia had a defect in TPO or c-Mpl (41,[2,3]). It was suspected to have a role in the differentiation of megakaryocytes to platelets (41). Megakaryocytes are immature platelets derived from haematopoietic stem cells, via megakaryopoeisis, with the help of various cytokines (Figure 1) (45). They are larger than platelets, consisting of organelles, granules and soluble macromolecules bound within a cell membrane (45). As seen in the diagram, megarkaryocyte organelles are fragmented to form proplatelets (45). These are long and thin cells, with hallmark features, consisting of swollen tips, which constitute the cell organelles and granules (45). The shape is made up of overlapping microtubules (45). The cell content is further phagocytosed by macrophages prior to entering peripheral circulation (45). The formation of proplatelets are dependent on environmental factors, for example during inflammation, synthesis is increased due to the rapid consumption of platelets (41). TPO proliferate megakaryocytic activity by stimulating stem cells to enter the G0 phase of the cell cycle (1). Its involvement does not stop at platelets, as it also stimulates activity of other stem lines. This shows that TPO is of great importance in the formation of the blood cells. 1.1.3 Pathophysiology of thrombocytopenia The cause of thrombocytopenia is of great importance to clinicians. To establish the correct treatment of patients, it is important to identify the source of the condition and its pathophysiology (17). There are many causes of thrombocytopenia; 2 of the main mechanisms include: Hypoproduction of platelets Hyperdestruction of platelets Hypoproduction Decrease in platelet production is associated with suppression of thrombopoiesis, resulting in megakaryocyte hypoplasia within the bone marrow (50). There are several factors, which may contribute e.g. exposure to radioactive substances, such as chemotherapy and radiotherapy (50). A defect in the stem line can be due to haematological malignancies, such as acute leukaemia, aplastic anaemia, myelodysplastic syndrome and multiple myeloma. In the hypoproduction of platelets, there is a decrease in all progenitor cells of platelets, thus an increase in plasma TPO and a decrease in immature platelets seen in blood Hyperdestruction An increase in destruction of platelets in peripheral blood may be due to sequestration of platelets by the spleen, via reticuloendothelial system (22). To compensate for the loss of platelets, the bone marrow releases immature platelets into circulation, indicating normal megakaryocytic activity (5). Hyperdestruction conditions can be further classified into immunological causes, such as idiopathic thrombocytopenia purpura (ITP) and non-immunological causes, e.g. disseminated intravascular coagulation (DIC) (23, 34). ITP continuing for periods longer than one year is known as chronic ITP (7). The condition is characterised by mucocataneous bleeding and a decrease in platelet count, often associated with the humoral cell-mediated mechanism (7). It is proposed that the complement pathway mediated by anti-platelet antibodies, may be a contributing factor (7). 1.1.4 Treatment of thrombocytopenia The severity of the abnormality varies from chronic to acute and is commonly associated with bleeding (10). Therefore the treatment of thrombocytopenia is dependent on the progression of the symptoms. There are many management schemes available to patients with this condition, one being TPO drug therapy, such as Electrombopag and AM G531 (45). The molecules of TPO bind to c-Mpl receptors, stimulating megakaryopoiesis (45). In many cases, there is a dramatic decrease in platelet count, resulting in excessive abnormal bleeding. The loss of whole blood is likely to be managed with red cell transfusion followed by other blood products. Due to the cause being thrombocytopenia, the patient is likely to need platelet transfusion. National blood transfusion guidelines state the platelet threshold as 20109/l (___). This would be decided by clinicians and consultants. 1.2 Historical Review 1.2.1 History of Platelets It wasnt until 1962 that platelet function was truly understood (44). Platelets named by Bizzozero was first detected in the mid 19th Century by Max Schulitz (44,45). They were noted as being the smallest blood cells, equivalent to 1/10 of erythrocytes (44). Following on from this theory, Bizzozero in 1882 studies these cells in vivo, using microscopy and detected platelets to consist of adhesion qualities, which was significant during vascular damage (45[2,3]). It was later suspected to play a role in thrombosis (44). 1.2.2 History of reticulated platelets Reticulated platelets were first observed in 1969 in peripheral blood of dogs, following acute blood loss. Ingram and Cooper-Smith (1969) used methylene blue to stain the RNA of cells, based on which a count was achieved (13). They were microscopically shown to be more reactive than mature platelets and have resemblance with reticulocytes, thus was named reticulated platelets (13, 18). Further investigation showed reticulated platelets to be RNA containing immature platelets derived from megakaryocytes, in the bone marrow (4,10). Similarly, Boayse and Rafelson observed the same platelet characteristics in humans, which then lead to opportunities for greater research into the area (35). By 1970, megakaryocytic progenitor cells could be detected, followed by the identification of growth factors responsible for differentiation of stem cells in 1980 and 1990 (45). To date, several discoveries have been concluded, which has lead to a better understanding of the mechanism. This has resulte d in advances in the diagnosis of thrombocytopenia. Based on reticulocyte analysis, Kienast and Schmitz introduced a fluorescent dye; thiazole orange to stain the nucleic acid, using flow cytometry (24). 1.2.3 History of thrombocytopenia The clinical symptoms of epitaxis and pupura were first classified with thrombocytopenia by Brohm, Kraus and Denys in 1883 (56). Later in the year, Kaznelson associated thrombocytopenia with a destruction of platelets (55). By 1946, increase numbers of megakaryocytes were seen in the bone marrow of patients with low platelets, forming the basis of idiopathic thrombocytopenia purpura (ITP) repectively (56). 1.2.4 Diagnosis In 1953, Brecher et al developed the first manual phase microscopy (55). Using counting chambers, platelets could easily be identified from red cells and counted (55). This method was soon replaced in 1950 by the Coulter principle, followed by automation in 1970 (55). Since then, there has been a vast improvement in the counting of platelets. The discovery of the light microscopy has also helped in achieving this and is still used in diagnosing thrombocytopenia to date. However, in the last decade, Sysmex have designed new upgraded software, designed for Sysmex XE2100 and XE5000 analysers. It has adopted the flow cytometry technique discovered by Kienasr and Schmitz, where reticulated platelets can be measured, in the form of immature platelet fraction (IPF) (11). 1.3 Discussion 1.3.1 Diagnosis of thrombocytopenia Preliminary studies consisted of platelet counts to be achieved microscopically (44). It wasnt until 1962 that platelet function was truly understood (44). A great deal of time and research has resulted in implementation of various specialised tests. Current diagnostic methods Thrombocytopenia can be an incidental laboratory finding or suspected from clinical feature presented by patients (40). Characteristics seen include bruising, purpura and bleeding. The bleeding condition may progress to severe forms (27). Therefore, the importance of diagnosis cannot be emphasised enough. Screening consists of full blood count marked with a decrease in platelet count followed by morphology examination for confirmation of results. On many occasions, larger megakaryocytes are released in peripheral, which may be visible by microscopy. Currently, a bone marrow examination is the gold standard method for detecting autoimmune thrombocytopenia (5). It investigates megakaryopoietic activity, where a hypoplastic image indicates decreased production (17). A bone marrow aspirate is not desired by patients, as it is an invasive and uncomfortable procedure. The method is vulnerable to sampling errors and examination can be subjective (22) There is limited specialised testing ava ilable to achieve this information, thus is crucial, especially in chronic thrombocytopenia, where 30% of cases are due to immune reaction or cytokine associated (45). Another crucial test includes plasma TPO levels. This is carried out by ELISA (Enzyme-Linked ImmunoSorbent Assay), using anti-TPO monoclonal antibody against recombinant TPO (50). This technique is expensive and time-consuming (2). Plasma TPO concentration have are reported to increase in hypoproduction conditions and normal in ITP (22) Plasma Glycocalicin (GC) levels can also be examined. It is a hydrophilic fragment made up of carbohydrates, which forms part of the ÃŽÂ ±-subunit of the platelet glycoprotein membrane (22). Low levels have been suspected in thrombocytopenia due to decreased production, and elevated in ITP (22). Thrombopoiesis is cytokine-mediated; therefore it would be useful to determine the expression of c-Mpl, as mutations in the gene have been identified in conditions such as congenital amegakaryocytic thrombocytopenia (50). This may be achieved by proteomic assays. Immature platelet fraction (IPF): the future diagnostic tool Over the past years, there have been several advances in detection of reticulated platelet. After years of research, Sysmex have introduced an automated flow cytometric method on the XE2100 and XE5000 analysers (11). It uses upgraded software to calculate an accurate measure of immature platelet fraction (IPF). The cells obtained from the peripheral sample is stained using fluorescence dyes and passed through a semi-conductor diode beam, where approximately 30,000 cells are counted and displayed on the basis of cell size and RNA content (12). The data is converted into a graph, showing the RNA content and cell size as forwards scatter and side scatter (figure 2)(12). Many authors have commented on the positivity of the technique in the diagnosis and management of patients (3). IPF was shown to be increase in ITP patient of a study performed by (5). 46 AITP patients had a median IPF of 17.4%, signifying the probable increase in megakaryocytic activity occurring in the bone marrow (5). Abe et al. (2006) conducted a similar study comparing healthy volunteers with patients diagnosed with thrombocytopenia (17). It was proposed that patients with ITP have a significantly increased IPF (17). This was agreed by (3,[8]), as ITP cases with platelet count >50 was observed to have an increase in numbers varying from 2.3-52.1%, and patients with A similar trend was observed in DIC patients by _____(16). Comparably, a positive correlation with D-Dimer was noted, whereas the data was inversely proportional to platelet count (16). DIC is commonly associated with a decrease in platelets, due to the intravascular formation of clots (16). In response, the bone marrow releases immature platelets into circulation, increasing the count (16). A study which compared hypoproduction and hyperdestruction of platelets showed a significant deferent between the groups (34). The mean IPF in subjects with decreased production was 7.5%, whereas in-patient with ITP and DIC, the mean IPF was 30.0% (34). This is evident that IPF can be used as a marker to distinguish between hypoproduction and hyperdestruction of platelets (34). Thrombocytopenia can be seen in patients with HIV, as they are most probably immune-compressed, thus are more vulnerable to infection. According to(8, [Briggs et al]), patients suffering from infections are more likely to have reduced platelet count, which explains why 40% of HIV patients in (8)s investigation were observed to have a low platelet count and raised IPF (8). IPF is a very quick and useful technique. The data obtained can be used for various clinical applications (2). It is relatively inexpensive and commercially available, therefore its use in monitoring drug therapy for bone marrow malignancies can be beneficial (2). (4) has shown the positive use of IPF in monitoring patients on chemotherapy, as well as (37), who reported IPF having 70% predictive value for detecting early platelet recovery (4, 37). The platelet count and IPF was monitored post exposure to chemotherapy. During the process, 3 pools of platelets were transfused. Completion of the second transfusion resulted in an IPF peak of 11.3% at day 11 (4). The increase in IPF indicates the existence of immature platelets in peripheral blood, predicting the increased release of cells from the bone marrow, which would eventually result in a normal platelet count. The improvement in platelet numbers was seen 3 days post transfusion (4). Within this period, another pool of platelet was given (4). Based on the results, the last transfusion was not required, thus could have been avoided (4). Briggs at al. (4, [3]) discovered similar findings to (4) and concluded IPF a better parameter. A similar scenario was presented by (10), who monitored patients undergone haematopoietic stem cell transplant (10). There was a rise in IPF, 3 days prior to platelet count. (4) and (5) also observed a decrease in IPF during the process, which was described by (4,[5]) as being part of the feedback mechanism of TPO or due to dilution of patient blood with prophylactic platelets (4,[5]). There was no significant difference observed between authors, suggesting good precision (5). Paediatric patients are most likely to show increase levels of immature platelets, as there is increased megakaryocytic activity during foetal and neonatal periods (3, 9). Previous reports obtained detected good sensitivity and specificity in IPF measurement using Sysmex XE2100 analysers. In majority of investigations, sensitivity was between 91-96%, with the specificity ranging from 67-100% for ITP (22). These figures suggest IPF to have a good degree of sensitivity. Specificity is widely distributed; however another study performed by (17) showed 86.8% sensitive and 92.6% specific. Therefore IPF (5) is an accurate parameter of reticulated platelets. Precision measurement reviewed by (14, [Biggs et al. 2004]) showed the coefficient of variance (CV) between 10-78% (14, [Biggs et al. 2004]). The vast variation of intra-assays questions the precision of the assay, when using XE2100 analysers. Other platelet indices Other platelet parameter that may be useful in determining thrombocytopenia includes mean platelet volume (MPV) and platelet distribution width (PDW). A decreased MPV is detected in bone marrow malignancies, where thrombocytopenia is present, however levels are shown to increase in myeloid leukaemia (M1) (11). PDW is a good indicator in thrombocytopenia of autoimmune cause, as the variation of the size of platelets marks the types of platelets available in peripheral (11). These parameters are commonly used in conjunction with morphology, IPF and TPO as individually, they have minimal clinical significance due to its lack of standardisation and instability with samples embedded in EDTA anti-coagulant (11). 1.3.2 Clinical Management and utility of IPF In severe cases with the need for rapid platelet increase, prophylactic platelet transfusions are given (18). National blood transfusion guidelines state the platelet threshold as 20109/l (___). The platelet count may vary from one analyser to another and may be dependent on the method used to detect the cells, as (12) compared the impedance method to the reference immune count (12). It was showed a decrease in correlation with decrease in platelet count (12). A change in the threshold would have a direct affect on the sensitivity and specificity, as adopting a higher threshold would result in false negatives and adjusted the count to about 10109/l would raise false positives (12). In comparison, the optical fluorescence method showed a good correlation (12). (10,[2,3]) studied the platelet transfusion guidelines and suggested a more accurate marker to detect early marrow activity to be used (10,[2,3]). (17) proposed the use of IPF (17) Chemotherapy treatment due to haematological malignancies can result in myelosuppression of bone marrow (27). It is important that these patients are monitored regularly. Currently, the need to transfuse platelets is dependant on clinical observation and platelet count. An early report from the national external quality assessment scheme (NEQAS) has shown a varying coefficient of variation (CV) between 20-60% when measured using automation (27[Parlar-William 03(NEQAS__ 2003)). It has been reported that the accuracy of the measure of platelet count decreases as the rate of thrombocytopenia increases (27). Therefore, a more sensitive marker would be beneficial. IPF has been shown to have capabilities of a good diagnostic marker. Several authors have discussed its use in monitoring and management with platelet transfusion; however its use in the clinical field is yet to be established (17). It is believed that this preliminary study will enable further investigations into the field at K ing George Hospital, which will eventually result in the positive use of IPF, to aid in diagnosing and monitoring of thrombocytopenia and determining treatment, respectively. 1.4 Future Prospects In the last decade, there have been many discussions on the diagnostic use of immature platelet fraction. Several studies have demonstrated the parameter to be beneficial in routine haematology laboratories for the diagnosis of thrombocytopenia. Regardless of the intensive studies performed, its use is yet to be established. Investigations carried out have shown up to a 3 days increase in IPF prior to platelet count during recovery of patients undergone chemotherapy. This is evident that it is a more useful marker for predicting a rise in platelet count, thus may aid in preventing unnecessary platelet transfusions from occurring. As stated by many authors, the lack of standardisation and questionable specificity has limited it from progressing. Therefore, a study confirming these findings would be useful. An audit can then be carried out, showing its effects follow the change, which can aid in interpreting the best possible technique for diagnosis of thrombocytopenia and monitoring chemotherapy patient. If successful, a larger secondary study can be performed, where a threshold for IPF can be calculated for clinical decisions regarding platelet transfusion. Hopefully, in the near future, IPF will be incorporated into routine laboratories for diagnosis of thrombocytopenia and management of patients with haematological malignancies. This would, in-time improve patient care and cost management of blood transfusion. Based on the above information, a question is asked; is IPF a good indicator of bone marrow function, which can be used to diagnose and monitor thrombocytopenia and help make clinical decisions regarding platelet transfusion? WORD COUNT: 3,140 References Section 2: Design Study 2.1 Introduction Thrombocytopenia is a common haematological condition, which if not treated, can progress to bleeding abnormalities. It is diagnosed routinely at King George Hospital via a full blood count. Further action consists of morphology assessment and bone marrow examination. The bone marrow aspirate is the final step, only performed if diagnosis is not identified. It is an invasive technique, thus not favoured by patients. A new parameter on the Sysmex XE-2100; known as immature reticulated platelet fraction (IPF) has been developed, which targets this problem. It is a measure of reticulated platelets; a form of immature platelets found in peripheral blood. It has been considered to be a true reflection of thrombopoietic activity of the bone marrow. IPF can be detected by a quick, simple and non-invasive technique, which can help in identifying the pathophysiology of the condition. By investigating the parameter in peripheral blood, a prediction can be made on the status of the bone marrow recovery in chemotherapy patient. Therefore it may be a beneficial marker in monitoring of therapeutic patients and in aiding clinical decisions regarding treatment, i.e. platelet transfusions. Based on the information above, the following aims, objectives and hypothesis are drawn, which form the foundation of the study. 2.1.1 Aim To determine if IPF can be used as a diagnostic marker to identify the pathophysiology of thrombocytopenia. To determine if IPF can be used as a predictive marker to assess bone marrow function in chemotherapy patients. To determine whether IPF can be used to help clinical decisions regarding treatment with prophylactic platelet transfusion. 2.1.2 Hypothesis IPF is a good indicator of bone marrow function, which can be used to diagnose and monitor thrombocytopenia and help make clinical decisions regarding platelet transfusion. 2.1.3.Objectives Determine the reference range for IPF at King George Hospital. Determine the stability of IPF measurement during storage Determine the precision of the IPF assay. Compare IPF values for thrombocytopenic patients with different clinical conditions in order to identify its use in determining the pathophysiology. Determine whether IPF predicts a rise in total platelet count in-patient with bone marrow suppression. Determine in how many cases monitoring of IPF could have prevented the need for platelet transfusion 2.2 Research Plan 2.2.1 Flow Chart Figure 3: flow chart of sequential events to take place to accomplish the study 2.2.2 Timeline Table 1: timetable consisting of events and the time in which is aimed to be completed Month (2010-2011) Task Comments July 2010 Obtain 200 EDTA samples from patients with normal full blood counts and perform IPF analysis using Sysmex XE2100, to determine reference range View patients clinical details provided. Samples should have a normal full blood count results. July 2010 Measure the stability and precision of IPF Repeat analysis at 0hrs, 3 times to calculate the precision of the assay. Analyze 50 samples with normal full blood count over a 48hr at two different temperatures. July-December 2010 Identify thrombocytopenic patients and categorise into group 1 and 2 Measure the IPF Monitor IPF and PLT count of chemotherapy patients. Most samples will be taken from the haematology/oncology unit at King George and Queens hospital For each patient, collect the full blood count results. December 2010 Perform statistical analysis on the information gathered January -March 2011 Write up first draft Meet up with supervisor and add any suggestions and improvements made by supervisor April -May 2011 Complete project write up June 2011 Hand into campus office Make sure two copies are submitted. 2.3 Experimental Approach The study protocol is awaiting ethical approval from the Research and Development (RD) department of Barking, Havering and Redbridge university trust (BHRUT). This must be awarded before the practical commences. All analysis will be performed in haematology laboratory at King George hospital and is aimed to be completed by December 2010. 2.3.1 Sample collection and criteria Samples will be collected from King George and Queens hospital with a minimum of 2-3 ml of blood, taken by venepuncture in anticoagulant ethylene diamine tetracetic acid (EDTA). All data processed will be from adult samples, thus this study is not valid for paediatrics or neonatal. In the study, normal will be defined as a patient with a full blood count within the hospital reference range, excluding any haematological abnormalities or unexplained clinical symptoms. Samples selected will be from patients samples requested for a full blood count between 20-50 years of age, with no bias towards sex. Thrombocytopenia is defined as a platelet count of Group 1: Hyperdestruction Group 2: Hypoproduction Before executing the practical, performance of the analysers needs to be checked. The internal quality controls used are purchased from Sysmex and analysed twice a day to ensure quality of the machines. Other quality measures taken include participation in the national external quality assurance scheme (NEQAS) and the Addenbrookes program, run weekly. 2.3.2 Reference range The initial step consists of generating a reference range of IPF (%). To accomplish this, 250 normal patient samples will be analysed on the Sysmex XE2100 analysers. The data will be tabulated and the reference range will be calculated as mean +/- 1.96SD of the normal distribution. 2.3.3 Validation Precision The precision of the test will be determined by repeating IPF analysis five times on 50 normal samples. The standard deviation (SD) and coefficient of variation (CV) will need to be calculated. Stability The stability of immature platelets in EDTA will be established by analysing 50 normal samples kept in different conditions. Each sample will be separated into 2 aliquots, one, which will be kept in the fridge between 2-8Â °C, and the other, which will be kept at room temperature at about 20-25Â °C. The room temperature and fridge temperature will be monitored daily. Each sample will be analysed at 24hrs and 48hrs. The IPF at 0hrs will also be recorded. The data will be tabulated and presented as a scatter diagram. The best condition for storage of samples will be identified along with the time frame of analysis. 2.3.4 IPF analysis Immature platelet fraction will be analysed in the RET chamber of the Sysmex XE2100 analyser (Sysmex, Kobe, Japan), using upgraded softawre. 4.5ml of EDTA blood will be aspirated via the sample rotor valve. The blood will then be diluted in 1:200 using 0.8955ml RetSearch (II) diluent, before being stained with 18ÃŽÂ ¼l RetSearch (II) dye for approximately 31 seconds. 2.8ÃŽÂ ¼l of the stained and diluted sample will enter the optical detector block. With the use of flow cytometry, the sample will go through a semi-conductor laser beam. The samples are then counted and separated based on cell size and RNA content. This will appear as an image of forward scatter and side scatter. Thrombocytopenia detection in group 1 and 2 30 samples for each group needs to be obtained to continue with the study. Patients of group 2 will be selected on the basis of bone marrow examination. The samples will be analysed for a full blood count and IPF, where the data will be recorded in a table. Further unpaired t-test analysis will be carried out to establish the relationship between platelet count and IPF, which can then be used to determine whether IPF is a better marker than platelet count in detecting thrombocytopenia and the underlying cause. Monitoring thrombocytopenia in chemotherapy patients The use of IPF in monitoring patients on chemotherapy will also be investigated. The hypothesis states IPF to be used to monitor thrombocytopenia and help make clinical decisions regarding platelet transfusion. To prove this, 50 patients with thrombocytopenia post chemotherapy will be monitored for 14 days. The platelet count and IPF will be recorded along with any transfusion that may be given. 2.4 Data and Statistical Analysis To perform statistical analysis and ease interpretation of results all raw data will be tabulated and presented in the appendix of the final project. The design of the tables can be seen below. 2.4.1 Analysis for Reference Range Table 2: shows raw data used to determine reference range of IPF (%) Sample IPF (%) PLT (x109/l) Age (yrs) Sex(m/f) The normal samples selected will be from patients between the ages 20-50 years. 2.4.2 Validation Precision Table 3: shows the IPF (%) value obtained at each repeat interval, Sample 1 2 3 4 5 The data will be used to determine the precision by calculating the standard deviation of the mean and CV (%). Stability Table 4: shows the IPF (%) data over 48% of samples stored at different temperatures Sample 0 hrs (Â °C) 24 hrs (Â °C) 48 hrs (Â °C) 2-8Â °C

Cheating :: essays research papers

~~~~~~ Cheating ~~~~~~ Cheating, We've all done it at least once in our lives, in all types of situations. Its human nature to want to win, and some of us will go against the rules to do so. It can be harmless, but in many cases it is annoying, or even hurtful. So, why was cheating and certain zone hacks become such a large problem in the Age games? Anonymity plays a big part in this. Behind the buffer zone of a computer screen and several hundred miles of telephone wire, people don't have to worry about upsetting someone else by playing unfairly, cheating, or exploiting bugs. Its also easy: it's far easier to download a hack, and get an advantage in a game than to actually practice and become good. For example, way back when I was playing a lot of AoE over the Zone. I faced up against a player with a name such as CrackDevilz or something similar. Two minutes after the game started he had sent an attack with an obscene amounts of units, all the while taunting and even boasting about his ability to cheat. Another factor that adds to this problem is the lack of maturity or even common courtesy in many of the players in the Age community. They simply don't care about wasting other people's time, upsetting others, or unbalancing a ladder or league system that someone has put a lot of time into creating. When these people do cheat, they often do not refrain from crude insults or taunts. This isn't a problem for experienced players; most people I know would just simply laugh at the idiocy of their opponent, but for new players, it can be pretty disheartening. In many ways these cheaters can have a very bad effect on the Age games. Some new players can actually be scared off or even turned away from a game simply from a single bad experience. They may assume all players they will meet are immature and rude, and just not put any time into trying to play the game again. This line of thought leads into another problem found in the zone. The rating system! To be honest, I don’t like it; players become too obsessed with there ratings. Have you ever lost a game and went â€Å"DAMN IT!† not necessarily because you lost, but because when you look at your nick again it will be down 8 points.

Discussion Post Essay

New Format Requested this week While the format is to be changed thisweek, you are still required to make 3 postings; one original post and comment on two other student’s post. ORIGINAL POST REQUIREMENTS: You are to apply the major topics covered in the course (finance/accounting, economics, marketing) to your company and provide an â€Å"analyst’s report†. 1) (Apply Marketing techniques to:) create an interesting, unique or otherwise attractive catch line (humor works great for me! ) as your post title. Make a recommendation (can be here AND in your subject line) (some of you may not feel you have enough â€Å"experience† where your opinion (i. e. , recommendation) is â€Å"worth something in this world†Ã¢â‚¬ ¦. however note, you may have more experience NOW than some analysts at major investment banking houses! (scary I know! )) 3)(Use your corporate report to:) provide certain and specific quantitative analysis of your company. DON†T repeat your entire report†¦. but provide highlights†¦.. as some examples: Net Income rose 20% from 2008-2011 to $1. 35 billion Expenses dropped†¦.  by 15% Shareholder equity (highlights mean â€Å"outlyers† of data†¦.. especially NEGATIVE information 4) (Use some economics learned†¦. predict macro and micro â€Å"futures†)†¦.. describe what Macro world events have affected your company (global eco slow-down†¦. price of oil) †¦.. even micro events (consumption among consumers w as down due to†¦. )provide sensitivities for world events on your corporation and how it will affect that company’s future activities. Provide predictions about future macro economic events and how your company will react going forward. The Network & Space Systems segment is engaged in the research, development, production and modification of products and services to assist its customers in transforming their operations through network integration, information, intelligence and surveillance systems, communication, architectures and space exploration. The Global Services & Support segment is engaged in the operations, maintenance, training, upgrades and logistics support functions for military platforms and operations. The Boeing Capital Corporation segment facilitates, arranges structures and provides selective financing solutions for its commercial airplanes customers. In the space and defense markets, it primarily arranges and structures financing solutions for its Boeing Defense, Space & Security government customers. Its portfolio consists of equipment under operating leases, finance leases, notes and other receivables, assets held for sale or re-lease and investments. The company was founded by William Edward Boeing in 1916 and is headquartered in Chicago, IL. http://www. marketwatch. com/investing/stock/ba/profile 2) The Boeing Company has a long history of providing complex systems and integrated assembly’s to its customers. 3) The Boeing Company is headquartered in Chicago IL. In 1997 Boeing and McDonnell Douglas merged to form what is the Boeing Company of today. This was approximately 1 year after Boeing acquired Rockwell Corporations Space and Defense division. The company has over 249 subsidiaries. The largest competitor on the commercial side is Airbus a division of EDS and the largest competitor on the Defense, Space and Security side is Lockheed Martin with many other companies lining up for second place. In order for Boeing to maintain it’s market share the company has had to continually research and develop new products in both major business units. Notes for special consideration† 1. Cash and cash equivalents increased from $5,359 billion to $10,049 billion from 2010 to 2011 2. Retained Earnings rose from $24,784 billion to $27,524 billion during the period of 2010 to 2011 3. Net Earnings rose from $1.3 billion in 2009 to $4. 02 billion in 2011 4) Boeing is a company that is always going to be challenged. The challengers for the Defense, Space and Security market typically have come from within the US but that is starting to change. EADS which is the largest defense business in Europe is continually trying to enter US ma rkets. Also Airbus which is a subsidiary of EADS is the most prominent competitor in the commercial segment but many countries such as Japan, China, Brazil and Canada are working very hard to position themselves as challengers to the commercial market. This will be a challenge for Boeing and Airbus for the next several decades. Commercial airline customers and airlines will continue to demand enhancements and improvements to the commercial airplanes and the service / cost associated with the. This will continue to drive performance by the manufacturers including Boeing which is the industry leader. The US government acquisition may decline depending on the outcome of the presidential and congressional elections. Boeing and it’s competitors in those markets will look toward no US markets to sell their products. Continued increase in energy and material cost will drive Boeings focus on keeping costs down. 5) Research and development are the single most important factor in keeping Boeing relevant for the future. Research and development expense amounted to $3. 9 billion, $4. 1 billion and $6.5 billion in 2011, 2010 and 2009, respectively. In 2009 this included $2. 7 billion alone for the new 787 commercial aircraft. Research and development costs also include bid and proposal efforts related to governme nt products and services, as well as costs incurred in excess of amounts estimated to be recoverable under cost sharing research and development agreements. Bid and proposal costs were $332 million, $355 million and $343 million in 2011, 2010 and 2009 respectively. R&D within the Defense, Space and Security business unit is primarily focused on supporting customer requirements and providing new technologies to meet the needs of military, security and space agencies.

Impact of Strike in an Organization Essay

The impact of strike to an organization Article by Rajalakshmi Rahul on June 11, 2012 Discuss now (0) Go to comments An organizational strike not only destroys the power of labor at its source while still professing theoretical support for the right to strike, but also causes many other losses. Labor on the other hand in demanding freedom to use the organizational strike is seeking an instrument fundamental to its rising power. The right to strike restricted in any way is the right shorn of some of its power (International Confederation for Free Trade Unions, 1989). The economic losses of the employer cause by a strike are incapable of precise calculation. The loss of profits is only one item in the total losses that an employer may suffer. The employer’s business may be crippled because of the loss of the market connection beyond the period of strike; goodwill may be lost; and the idle machines may get spoilt. Additional expenditure may have to be incurred on protecting the plant and on strike breaking activities (Howell, 2005). Publicity and propaganda are yet other items adding to its costs. Besides the loss of mental peace, respect and status in the community cannot be calculated in terms of money. The adverse affects of a strike on the workers are the loss of wages, and fringe benefits contracting of debts, personal hardships and loss of employment. It is difficult to assess the wage and production losses on account of a strike. Any calculation of wage losses from pay roll gives only a partial picture. In addition the strike may leave the union weakened and divided to the satisfaction of the employer Thus, strikes involve both economic and non economic costs for the employer and if at the extreme of strike he has to concede the demands of the striker’s additional burdens are imposed. However certain other elements which mitigate the losses also form a part of the economic calculation of the cost of a strike. References †¢Howell C (2005), Trade Unions and the State, Princeton University Press, New Jersey. †¢International Confederation for Free Trade Unions (1989), Employment and structural change in Indian industries, Cengage Learning, USA.

Free Essays on Death Of A Sales Man

A Tragic Hero in Arthur Millers â€Å"Death of a Salesman† Tragedy was a very controversial issue in literature until recent years. Recent figures in literature have set a clear definition for tragedy. Author Miller is one of these figures. Plays and novels have distinguished the definition of tragedy. According to the Merriam-Webster Dictionary tragedy is a serious piece of literature typically describing a conflict between the protagonist and a superior force and having a sorrowful or disastrous conclusion that excites pity or terror. Miller’s explains that a tragic hero does not always have to be a monarch or a man of a higher status. A tragic hero can be a common person. A tragedy does not always have to end pessimistically; it could have an optimistic ending. The play Death of a Salesman, by Arthur Miller, is a tragedy because its hero, Willy Loman, is a tragic figure that faces a superior source, being the American dream and the struggle for success. Loman also excites pity in the reader because of his defeat and his inability t o become a success or teach his children how to make their lives successful. Miller defines a flaw as â€Å"an inherent unwillingness to remain passive in the face of what one conceives to be a challenge to one’s dignity†¦Ã¢â‚¬  (Penguin USA) Loman fulfills many of the requirements of being a tragic hero. Willy is not â€Å"flawless† in his actions, which by Miller’s standards make him a tragic hero. It is not wrong for Willy to have flaws and it does not make him a weaker man but a tragic figure. Miller designed the play so that Willy could be a tragic hero and for this he needs to have a flaw. Willy’s flaw is that he is unable to see things in a more realistic perspective. Charley says something in the play that sums up Willy’s whole life. He asks him, "When the hell are you going to grow up?" Willy’s spends his entire life in an illusion. He sees himself as a great man that is popular and su... Free Essays on Death Of A Sales Man Free Essays on Death Of A Sales Man A Tragic Hero in Arthur Millers â€Å"Death of a Salesman† Tragedy was a very controversial issue in literature until recent years. Recent figures in literature have set a clear definition for tragedy. Author Miller is one of these figures. Plays and novels have distinguished the definition of tragedy. According to the Merriam-Webster Dictionary tragedy is a serious piece of literature typically describing a conflict between the protagonist and a superior force and having a sorrowful or disastrous conclusion that excites pity or terror. Miller’s explains that a tragic hero does not always have to be a monarch or a man of a higher status. A tragic hero can be a common person. A tragedy does not always have to end pessimistically; it could have an optimistic ending. The play Death of a Salesman, by Arthur Miller, is a tragedy because its hero, Willy Loman, is a tragic figure that faces a superior source, being the American dream and the struggle for success. Loman also excites pity in the reader because of his defeat and his inability t o become a success or teach his children how to make their lives successful. Miller defines a flaw as â€Å"an inherent unwillingness to remain passive in the face of what one conceives to be a challenge to one’s dignity†¦Ã¢â‚¬  (Penguin USA) Loman fulfills many of the requirements of being a tragic hero. Willy is not â€Å"flawless† in his actions, which by Miller’s standards make him a tragic hero. It is not wrong for Willy to have flaws and it does not make him a weaker man but a tragic figure. Miller designed the play so that Willy could be a tragic hero and for this he needs to have a flaw. Willy’s flaw is that he is unable to see things in a more realistic perspective. Charley says something in the play that sums up Willy’s whole life. He asks him, "When the hell are you going to grow up?" Willy’s spends his entire life in an illusion. He sees himself as a great man that is popular and su... Free Essays on Death Of A Sales Man Seeking the American Dream of Success Arthur Miller’’s â€Å"â€Å" Death of A Salesman†Ã¢â‚¬  could be described as a study in the American Dream ideology, a system that at times is indescribably brutal and at other times compassionates. Author Miller's plays are usually associated with real life issues filled with failure and disappointment. The author's main character, Willy Loman, is a traveling salesman that spends his whole lifetime trying to find success based on looks and popularity. Willy Loman is a product of this ever-increasing society, obsessed with measuring success by popularity and material wealth and unfortunately emphasizing these principles upon his family. For Willy Loman, to be liked was the definitive criterion of life success. The American dream of wealth and luck became Willy’’s dream, and it almost became reality. Willy realizes that in fact he has lived his life in vain, never achieving nor succeeding but remaining a shad ow of his ambition. It is this sudden insight that urges him into a fantasy, afraid to face the future. It is only through Willy’’s failure as a salesman that his innate desire for the outdoors is exposed. At the end of the play, Charley mentions, â€Å"â€Å"†¦Ã¢â‚¬ ¦ He was a happy man with a batch of cement †¦Ã¢â‚¬ ¦ so wonderful with his hands †¦Ã¢â‚¬ ¦ he had the wrong dreams, all wrong.†Ã¢â‚¬ . It has been often said that the play emphasize the path not taken may have been the right one, still Willy holds the inability to see who and what he is. Miller has created Willy’’s wife Linda in such a way, that it is difficult to confirm whether she is a positive or destructive force upon him. It is hard to understand why she allows this deception to rise to the level that it does. The love Linda holds for Willy is relentless. She sees herself as his protector, allowing him to laps into his illusions where he feels contentment. But i n her love for her husband she is ironically his destroyer. Linda in he...

Is black cohosh a safe and effective substitute for hormone Article

Is black cohosh a safe and effective substitute for hormone replacement therapy - Article Example She tries to evaluate if black cohosh is an effective and safe substitute for hormone replacement therapy. According to the facts presented in the editorial, it is rather palpable that approximately 85% of women in the world experience night sweats and hot flashes, which are closely associated with menopause. These symptoms are triggered by the hormones in the body of the individual. Research asserts that black cohosh is a herb that is used to deal with vasomotor symptoms as a substitute for the hormone replacement therapy. The herb is widely used in the United States and Europe (Becker, Letham & Stoehr, 2009). However, black cohosh has numerous side effects to the women. As stated above, there are several inconsistencies that have been associated with the use of black cohosh. Some of these discrepancies are related to the dosing and side effects of the drug. Some of the complications that are able to result from the use of black cohosh include hepatitis, muscle damage and liver failure among other conditions. Several experts have critically evaluated the efficacy of the black cohosh for the vasomotor symptoms (Becker, Letham & Stoehr, 2009). In the clinical trials, there were several adverse effects of the drug to the

John Quincy Adams Article Example | Topics and Well Written Essays - 500 words

John Quincy Adams - Article Example One of his journal entries at forty-five is a statement filled with reflection upon a continuous personal struggle with insecurity as the country’s president passionately endeavored to resolve his own indifference in serving and shaping the American nation based on convictions established by his roots. To JFK, even if this meant desertion by the Federalist Party, his depicts a real story of unusual courage, a point when a reader shifts perspective from the common view of a heroic political figure but one may readily admit that the bravery shown through the profile of Adams is by itself justified. It truly takes a huge amount of courage to be able to convey imperfections across a multitude who are in typical recognition of flawless leaders only. One of his journal entries at forty-five is a statement filled with reflection upon a continuous personal struggle with insecurity as the country’s president passionately endeavored to resolve his own indifference in serving and shaping the American nation based on convictions established by his roots. To JFK, even if this meant desertion by the Federalist Party, his depicts a real story of unusual courage, a point when a reader shifts perspective from the common view of a heroic political figure but one may readily admit that the bravery shown through the profile of Adams is by itself justified. It truly takes a huge amount of courage to be able to convey imperfections across a multitude who are in typical recognition of flawless leaders only. Daniel Webster As an ideal example of a man with an authentic word of honor, Pres. J. F. Kennedy paid tribute as well to Daniel Webster who did not cease at aiming to win favor for the cause of the Union while working to impede the natural course of the Civil War. Like the few other notable profiles, Webster occurs to be characterized in Kennedy’s creation as a man who deserves even the reverence of the modern world for taking grave risks in the act of unifying the States at the expense of his profession and the economy attached to it. In all eloquence, D. Webster expressed his determination to pursue his undaunted convictions toward the preservation of the Union to the extent of not receiving a due acknowledgment after tedious hours of dedicated speech and as if he were constantly at the frontline of the stiff rivalry between the irreconcilable South and North. One evidently identifies in his case one of JFK’s most admired traits, as firmly standing for what the man co nsiders as his sense of fervent and unbreakable truth. This had been adequately manifested in Webster’s manner of persuasion in tone or his astounding presence of spirit and verbal delivery that could be felt spontaneously radiating from out of a solid core or a well-integrated whole where mind and heart are a single entity so that audience at the time acquired the impression that ‘he looked like one, talked like one, was treated like one, and insisted he was one (Kennedy 53).’Â